Course Schedule

Morning: Theoretical part

Topics:

• Description of behavior: Executive operations, symptoms of ADHD in DSM-IV and ICD-10 
  
• Genetic and environmental factors: complex genetic disorder, environmental risk factors, comorbidity
• Imaging correlates: PET and MRI, QEEG, theta beta ratio as inattention index
  
• QEEG endophentypes of ADHD
• ERPs correlates: Selective attention, working memory, engagement operation, response inhibition, monitoring operation
• ERP endopenotypes:  Decrease of response suppression and visual related components
• Dopamine hypothesis of ADHD: Increased level of DAT, noradrenaline transporter
• Other diagnostic tools for ADHD
• Treatment: Psychostimulants,  neurofeefback, beta enhancement/theta suppression protocol, working memory tools, relative beta training protocol, normalization of executive ERPs components, Transcranial Direct Current Stimulation.
  

Afternoon: Practicum

Examples of EEG records in eyes open, eyes closed and two stimulus GO/NOGO tasks taken from a group of ADHD children and norms will be given to the attendees. The task will be to analyze the cases by

1) deartifacting,
2) computing spectra and ERPs,
3) comparing the data to the HBI reference database,
4) comparing behavioral parameters to the reference data,
5) attributing the whole set of data to an ADHD endophenotype and
6) constructing a specific treatment protocol for the patient.

Attendees are also encouraged to bring their own cases to the class in order to analyze them in front of the class.

Morning: Theoretical part

• Description of behavior: Involvement of the sensory, executive and affective systems, positive and negative symptoms, dysfunction of the executive system
• Genetic and environmental factors:  Multiple genes are involved,  environmental risk factors
• Imaging correlates: MRI, QEEG, ERPs correlates, mismatch negativity as an indicator for schizophrenia? CNV and PINF (post imperative negative fluctuation), a lack of anteriorization of the NOGO positive wave in the GONOGO paradigm, engagement operation, monitoring operation 
• Dopamine hypothesis of schizophrenia: Excess of striatal dopamine receptors, neural net model
• Other diagnostic tools
• Treatment: Antipsychotic agents, electroconvulsive therapy,  psychosurgery, neurofeedback 

Afternoon: Practicum

Examples of EEG records in eyes open, eyes closed and two stimulus GO/NOGO tasks taken from a group of schizophrenic patients and norms will be given to the attendees. The task will be to analyze the cases by

1) deartifacting,
2) computing spectra and ERPs,
3) comparing the data to the HBI reference database
4) comparing behavioral parameters to the reference data,
5) attributing the whole set of data to the schizophrenic or normal groups and 6) constructing a specific treatment protocol for the patient.

Attendees are also encouraged to bring their own cases to the class in order to analyze them in front of the class.

Morning: Theoretical part

• Description of behavior: History, symptoms, subtyping depression,  heritability, need for objective diagnostic system 
• Imaging correlates: PET, MRI, spectra asymmetry, ERP asymmetry, QEEG/ERPs assessment in a depressed patient, QEEG predictors of response to antidepressants
• Neuronal model: Monoamine hypothesis of depression, brain circuitry of depressed mood 
• Other diagnostic tools
• Treatment: Cognitive behavioral therapy, ECT and psychosurgery,  antidepressants, TMS, neurofeedback

Afternoon: Social event

Morning: Theoretical part

• Description of behavior: Symptoms
• Mediators:Association with cholinergic/GABA septal-hippocampal circuits,  cholinergic hypothesis of Alzheimer’s disease
• Neural net model: Theta bursts in healthy brain, increase of spontaneous theta activity in diseased brain
• Other diagnostic tools
• Imaging correlates:QEEG, ERPs.
• Treatment:  Acetylcholinesterase inhibitors, neurofeedback. 

Afternoon: Practicum

Examples of EEG records in eyes open, eyes closed and two stimulus GO/NOGO tasks taken from a group of patients with Alzheimer’s disease and norms will be given to attendees.  The task will be to analyze the cases by

1) deartifacting,
2) computing spectra and ERPs,
3) comparing the data to the HBI reference database,
4) comparing behavioral parameters to the reference data,
5) attributing the whole set of data to the Alzheimer’s or normal groups and
6) constructing a specific treatment protocol for the patient.

Attendees are also encouraged to bring their own cases to the class in order to analyze them in front of the class.

Morning: Theoretical part

• Effect of mediators on the brain systems (executive, sensory, affective and memory)
• Examples of effect of different drugs (Concerta, Straterra,…) on spectra and event related potentials
• How to construct your own reports: The steps of constructing your own report will be described
• How to write a summary of the report: What is important and what is irrelevant
• How to suggest a neurofeedback/tDCS protocol on the basis of a report: Bulldozer principle of neurofeedback and principles of tDCS.

Afternoon: Practice and Test

An example of EEG records in eyes open, eyes closed and a task condition of one of the shown patient groups will be given to the attendees. The task will be to make a report, summary and recommendations for therapy.  Attendees are also encouraged to bring their own cases to the class in order to make a report.